Two novel butanol rhamnopyranosides (1 and 2), along with nine known compounds (3-11), have been isolated from various non-polar and polar extracts of an Indian traditional herb, Euphorbia hirta. The structures of the new compounds were elucidated as n-butyl-1-O-beta-L-rhamnopyranoside (1) and n-butyl-1-O-alpha-L-rhamnopyranoside (2) by spectroscopic methods including IR, HR-FABMS, 1D and 2D NMR techniques.