Three new pyrrolidides, brachyamide A, brachyamide B and brachystine, have been isolated from Piper brachystachyum. The known amides, piperade, retrofractamide A and guineensine, the lignans pluviatilol, methyl pluviatilol (fargesin), sesamine, asarinine and the aromatic hydrocarbon pipataline, substituted cinnamic acids, methyl ester and sitosterol were also isolated and identified. Piper longum furnished a new long chain isobutyl amide, longamide, besides guineensine and the same lignans as isolated from P. brachystachyum. All the new piperamides were characterized by spectral studies and chemical degradation.