In addition to etioline two new alkaloids, solaspiralidine and a glycoside, were isolated from roots of Solanum spirale. Their structures were elucidated as (20R,25 xi)-23,26-epimino-3 beta,16 alpha-dihydroxycholesta-5,23(N)- dien-22-one and 3-O-(beta-D-glucopyranosyl)etiotine [(25S)-22,26-epimino-3 beta-(beta-D-glucopyranosyloxy)cholesta-5,22(N)-dien- 16 alpha-ol]. Copyright (C) 1996 Published by Elsevier Science Ltd