<jats:title>Abstract</jats:title><jats:p>The Amaryllidaceae family has proven to be a rich source of active molecules. As part of an ongoing project, we report a phytochemical study of <jats:italic>Hippeastrum morelianum</jats:italic> (Amaryllidaceae), from which we have isolated two homolycorine‐type alkaloids, the new 2α,7‐dimethoxyhomolycorine (1) and the poorly described candimine (2), as well as six known alkaloids: tazettine, pretazettine, 3‐epimacronine, haemanthamine, hamayne and trisphaeridine. For reference purposes, the NMR of the isolated compounds was unequivocally described, based on 2D NMR measurements including <jats:sup>1</jats:sup>H–<jats:sup>1</jats:sup>H COSY, <jats:sup>1</jats:sup>H–<jats:sup>1</jats:sup>H NOESY, HSQC and HMBC. Copyright © 2011 John Wiley & Sons, Ltd.