On the Alkaloids of Aconitum gigas LEV. et VAN. and the Structure of a New Base, Gigactonine

YAKUGAKU ZASSHI
1978.0

Abstract

The alkaloids of Aconitum gigas Lév. et VAN. which was collected in Hokkaido, were reëxamined. In addition to the reported lycaconitine, two known compounds, lycoctonine and atisine hydrochloride, and a new base, named gigactonine, were isolated. The structure of gigactonine was deduced from a few chemical reactions and its ¹³C nuclear magnetic resonance spectrum, and it was established that 18-O-methylgigactonine was identical with the known diterpenoid alkaloid, delsoline. From oxidation reactions and the above-mentioned correlation, the structure of gigactonine was established. Furthermore, bases I and V were also isolated from the same plant as the artifacts of lycaconitine.

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