As part of a systematic survey of the alkaloids of the Amaryllidaceae we wish to report the isolation of tazettine and lycorine from several Hymenocallis species. The alkaloid tazettine has been isolated from Lycoris radiatu, Narcissus tazettu, Ungernia sewerowii and Galanthus nivalis. Although Greathouse and Rigler have demonstrated the presence of unspecified alkaloids in H. qalvestonensis, the only chemical study of Hymenocallis spp. was conducted by Gorter who isolated lycorine from H. littoralis in 0.0015% yield. Lycorine appears to be the most wide-spread alkaloid of the Amaryllidaceae. The isolation of a crude alkaloid fraction from the bulbs was achieved by a conventional procedure. Nearly 90% of this crude fraction was soluble in benzene and concentration of the benzene solution gave most of the tazettine that could be isolated. A minute quantity of lycorine was detected in the benzene-insoluble residues. Tazettine and lycorine were identified by analytical data and rotation and by the preparation of known derivatives. The infrared absorption spectrum of the lycorine isolated was identical with that of an authentic sample. While the structure of lycorine has been largely elucidated, only portions of the tazettine molecule are known with certainty.