Structure and Synthesis of Benzoquinolizidine Alkaloids isolated from Alangium lamarckii

YAKUGAKU ZASSHI
1983.0

Abstract

Recent studies on the elucidation of the structures and stereochemistry of the Alangium alkaloids ankorine, alangicine, alangimarckine, desmethylpsychotrine, demethyltubulosine, and 10-demethylprotoemetinol by stereospecific synthesis have been reviewed. In these studies, the target molecules have been synthesized by the "lactim ether method" invented for the racemic series and by the "cincholoipon-incorporating method" for the chiral series. The syntheses of emetine, 9-demethylcephaeline, 10demethylcephaeline, and 9-demethylprotoemetinol by the latter method and the results of some preliminary studies have been also summarized.

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