First Total Synthesis of a Novel Monoterpenoid Isoquinoline Alkaloid, (.+-.)-Alangine.

Chemical and Pharmaceutical Bulletin
2002.0

Abstract

The structure including the stereochemistry of a novel monoterpenoid isoquinoline alkaloid, alangine, was confirmed by total synthesis via N-acyliminium cyclization to construct the isoquinoline skeleton and reductive cleavage of vinyl epoxide with Pd(0) catalyst.

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