The structures of the novel protein kinase C inhibitors K-252a, b, c and d.

The structures of the novel protein kinase C inhibitors K-252a, b, c and d. K-252a, a potent inhibitor of protein kinase C from microbial origin. Indolocarbazoles. 1. Total synthesis and protein kinase inhibiting characteristics of compounds related to K-252c. 2-aryl-indolyl maleimides - novel and potent inhibitors of protein kinase C Design of new inhibitors for cdc2 kinase based on a multiple pseudosubstrate structure UCN-01 and UCN-02, new selective inhibitors of protein kinase C. II. Purification, physico-chemical properties, structural determination and biological activities. UCN-01 and UCN-02, new selective inhibitors of protein kinase C. II. Purification, physico-chemical properties, structural determination and biological activities. The Shurosporine Producing Strain Streptomyces longisporoflavus Produces Metabolites Related to K-252a. Proposal for Biosynthetic Intermediates of K-252a. Isolation and Structure Determination of Novel Phosphatidylinositol Kinase Inhibitors, Echiguanines A and B, from Streptomyces sp. Isolation and Structure Determination of Novel Phosphatidylinositol Kinase Inhibitors, Echiguanines A and B, from Streptomyces sp.