Objective: Analysis the chemical constituents from the roots of Ficus hirta. Methods: The Ficus hirta Vahl. were extracted with 75% ethanol. Qualitative analysis of ethanol extracts was carried out by using high performance liquid chromatography-tandem mass spectrometry (LCMS-IT-TOF) and gas chromatography-mass spectrometry (GC-MS). Result: Twenty compounds were identified by LCMS-IT-TOF. Nine compounds were identified by GC-MS. Psoralens and bergapten were identified by LCMS-IT-TOF and GC-MS. Conclusion: LC-MS-TOF and GC-MS have identified 27 compounds, including 9 flavonoids, 6 coumarins, 3 organic acids, 3 organic alcohols, 2 organic esters, 1 terpene, 1 polyphenol, 1 alkaloid and 1 anthraquinone, which laid a foundation for further study of Ficus hirta Vahl. and its compound preparations. © Published under licence by IOP Publishing Ltd.