Total synthesis of the indole alkaloids henrycinol A and B

Tetrahedron
2014.0

Abstract

The total synthesis of new indole alkaloids henrycinol A and B were accomplished starting from L-tryptophan methyl ester. The key step is a stereochemically flexible Pictet-Spengler reaction governed by the presence or absence of an N-allyl group in the tryptophan precursor. The natural products henrycinol A and B were synthesized in good overall yield in eight and nine steps, respectively. (C) 2014 Elsevier Ltd. All rights reserved.

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