In the past few decades,Daphniphyllumalkaloids have attracted wide attention due to their unique synthetic pathways, complex structures, and diversified carbon skeletons. Since 2008, 144 newDaphniphyllumalkaloids from theDaphniphyllaceaefamily have been isolated. These compounds were found to contain a large number of novel skeletons. In this review, we discuss the structure, classes, plant sources, and bioactivities of the plant-derivedDaphniphyllumalkaloids reported between 2008 and 2020 and provide the basis for further studies.