des-7'-O-methylroraimine (compound 1) and epi-des-7'-O-methylroraimine (compound 2), two new isomeric bisbenzylisoquinoline alkaloids were isolated and characterized as a mixture from the rhizomes of Cissampelos sympodialis Eichl. The unambiguous structural elucidation of both isomers was performed with the aid of HR-ESI-MS, FT-IR, and NMR techniques including COSY, HMQC, HMBC, and NOESY. Copyright (C) 2013 John Wiley & Sons, Ltd.