18‐O‐Methylchaenorpine (1a) and iso‐18‐O‐methylchaenorpine (1b) two novel stereoisomeric spermine alkaloids were isolated from the roots of Aphelandra tetragona (VAHL) NEES. Their structures were established by chemical and spectroscopic studies. Copyright © 1989 Verlag GmbH & Co. KGaA, Weinheim