Eleven Lycopodium alkaloids with a lycopodine-type skeleton were isolated from the basic material of the whole plant of Huperzia serrata (THUMB.) TREV. (Huperziaceac). Among them, 12-epilycodoline N-oxide (= (12alpha,15R)-12-hydroxy-15-methyllycopodan-5-one N-oxide; 1), 7-hydroxylycopodine (= (15S)-7-hydroxy-15-methyllycopodan-5-one; 2), and 4,6alpha- dihydroxylycopodine (= (6alpha,15R)-4,6-dihydroxy-15-methyllycopodan-5-one; 3) are new compounds. Their structures were identified spectroscopically, especially by means of 1D- and 2D-NMR.