Synthesis of the novel isoquinoline enamide alkaloid polycarpine

Journal of Heterocyclic Chemistry
1981.0

Abstract

The synthesis of the novel enamide isoquinoline alkaloid polycarpine, (Z)‐1‐(2′‐hydroxy‐3′,4′‐dimethoxy‐benzylidene)‐3,4‐dihydro‐6,7‐dimethoxy‐2‐(1H)isoquinolinecarboxaldehyde, proceeding from commercially available 2′,3′,4′‐trimethoxyacetophenone in seven steps is described. The O‐methyl and O‐benzyl derivatives were also obtained. Copyright © 1981 Journal of Heterocyclic Chemistry

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