Structure and synthesis of nudiflorine

Tetrahedron
1966.0

Abstract

On the basis of physical and chemical studies nudiflorine, the new pyridone alkaloid isolated from the leaves of Trewia nudiflora Linn. has been assigned the 1-methyl-5-cyano-2-pyridone (II) structure which has been confirmed by an unambiguous synthesis. Nudiflorine is an isomer of ricinidine (I, R = H; R1 = CN) the demethoxylation product of ricinine (I, R = OCH3; R1 = CN). Biogenesis of nudiflorine and ricinidine has been discussed and their simultaneous synthesis accomplished. © 1966.

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