Three new alkaloids, (+)-N′-methylammodendrine (3), N-acetylhystrine (4), and the biogenetically intriguing smipine (9), have been isolated from Lupinus formosus and their structures determined. Other alkaloids identified were hystrine (1), (+)-ammodendrine (2), (−)-anabasine (5), (−)-N-methylanabasine (6), lupinine (7), and N-methylpelletierine (8). © 1974, American Chemical Society. All rights reserved.