Enantiocontrolled synthesis of (+)-aphanorphine from (R)-O-benzylglycidol: assignment of absolute configuration

Journal of the Chemical Society, Chemical Communications
1989.0

Abstract

Aphanorphine, a novel 3-benzazepine alkaloid isolated from the freshwater blue-green alga Aphanizomenon flos-aquae, has been synthesized in the antipodal forms starting from (R)-O-benzylglycidol to establish the absolute configuration of the natural product as (1R, 4R).

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