A new ester-alkaloid isolated from the rhizomes of Veratrum grandiflorum (Maxim.) Loesener fil., m.p. 235°, [α]15D –10.9°, was found to be 16-angelate of the alkamine which had been obtained from Veratrum oxysepalum Turcz. and characterized by Shimizu as zygadenilic acid -lactone. © 1962, The Pharmaceutical Society of Japan. All rights reserved.