Structure determination of epipachysamine-A (I), -B (VIIIa), -C (III), -D (VIIIb), -E (VIIIc), and -F (V), new alkaloids isolated from Pachysandra terminalis Sieb. et Zucc. (Buxaceae), was described herewith. Among these alkaloids, epipachysamine-B (VIIIa) is unique in that it has a nicotinamide grouping in the molecule. © 1967, The Pharmaceutical Society of Japan. All rights reserved.