In succession to the structure determination of a number of 3,20-diamino-5α-pregnane type alkaloids of Pachysandra terminalis Sieb. et Zucc., another new alkaloid, epipachysandrine-A, which was obtained from the weakly basic alkaloid fraction was investigated. The structure and stereochemistry of the alkaloid was proved to be represented by the formula Ia. © 1967, The Pharmaceutical Society of Japan. All rights reserved.