Synthesis and biological activity of C-6 modified derivatives of the glucosidase inhibitor 1-deoxynojirimycin.

Bioorganic & Medicinal Chemistry Letters
1992.0

Abstract

A novel 1-deoxynojirimycin derivative, (6S)-6-C-ethyl-1-deoxynojirimycin, was synthesized and tested on a set of α- and β-glucosidases. Its enzyme inhibitory activity against α-glucosidases from yeast and rice was superior to those of 1,5,6-trideoxy-6-fluoro-1,5-imino-D-glucitol, 1-deoxynojirimycin and its bicyclic analogue, castanospermine.

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