New deoxynojirimycin derivatives as potent inhibitors of intestinal α-glucohydrolases

Bioorganic & Medicinal Chemistry Letters
1997.0

Abstract

New N-alkyl, alkenyl and benzyl substituted DNJ derivatives incorporating a silicon atom in the substituent were synthesised. Kinetic parameters (K, t,z=) for inhibition of rat intestinal ~-glucohydrolases as well as human lysosomal ~-glucosidases were measured. New DNJ derivatives are potent and selective inhibitors of intestinal o~-glucohydrolases.

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