Synthesis, biochemical activity and behavioral effects of a series of 1,4,5,6-tetrahydropyrimidines as novel ligands for M1 receptors

Bioorganic & Medicinal Chemistry Letters
1992.0

Abstract

A series of novel tetrahydropyrimidines was synthesized and examined for Ml muscarinic receptor activity. 1,4,5,6-Tetrahydro-5-methoxycarbonylpyrimidine hydrobromide (la; CDD-0034-C) displayed a high affinity for muscarinic receptors in rat brain and stimulated PI metabolism in rat hippocampus. Compound la ameliorated memory deficits associated with lesions of the septohippocampal cholinergic system in rats.

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