Palladium-catalyzed synthesis of C3-substituted 3-deoxymorphines.

Bioorganic & Medicinal Chemistry Letters
1994.0

Abstract

The facile synthesis of a series of C3-substituted analogues of 3-deoxymorphine (2) by use of palladium-catalyzed reactions is described. Although none of the new compounds were as potent as morphine at either κ-, μ- or δ-opioid receptors, the μ-receptor selectivity of the C3-furyl derivative 7 approached that of morphine.

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