Pyridinomorphinans: Asymmetric synthesis of either enantiomer and opioid receptor binding selectivity

Tetrahedron Letters
1997.0

Abstract

Either enantiomer of a new class of morphinans in which the aryl ring is replaced by a pyridine ring can be prepared by sequential iminium ion-allylsilane cyclization and intramolecular Heck insertion. Pyridinomorphinan 5 exhibits high affinity for the mu opioid receptor. (C) 1997 Elsevier Science Ltd.

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