Topliss approach to the synthesis of biologically active substituted N-benzoyl taxol analogues

Bioorganic & Medicinal Chemistry Letters
1994.0

Abstract

A series of compounds, directed by the Topliss Operational Scheme, were synthesized and evaluated to investigate structure activity relationships of the N-benzoyl moiety of taxol. Evaluation of the newly prepared derivatives in the microtubule assembly assay and for cytotoxicity revealed that they possessed biological properties similar to taxol.

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