Literature

Abstract

A series of substituted 3'-phenyl tax01 analogues, directed by the Topliss Operational Scheme, were synthesized and evaluated for their biological activity. The novel analogues were prepared from baccatin III and N-acyl &lactams. Evaluation in the microtubule assembly assay and for cytotoxicity against B16 melanoma cells illustrated a modest influence of aromatic substitution on bioactivity.

DOI： 10.1016/0960-894X(94)85035-6

Synthesis and biology of substituted 3′-phenyl taxol analogues

Bioorganic & Medicinal Chemistry Letters 1994.0

Topliss approach to the synthesis of biologically active substituted N-benzoyl taxol analogues

Bioorganic & Medicinal Chemistry Letters 1994.0

Novel Biologically Active Taxol Analogues: Baccatin III 13-(N-(p-chlorobenzoyl)-(2′R,3′S)-3′-phenylisoserinate) and Baccatin III 13-(N-benzoyl-(2′R,3′S)-3′-(p-chlorophenyl)isoserinate)

Bioorganic & Medicinal Chemistry Letters 1992.0

Synthesis of biologically active 2-benzoyl paclitaxel analogues

Bioorganic & Medicinal Chemistry Letters 1995.0

Semisynthesis and biological activity of taxol analogues: baccatin III 13-(N-benzoyl-(2′R,3′S)-3′-(p-tolyl)isoserinate), baccatin III 13-(N-(p-toluoyl)-2′R,3′S)-3′-phenylisoserinate), baccatin III 13-(N-benzoyl-(2′R,3′S)-3′-(p-trifluoromethylphenyl)isoserinate), and baccatin III 13-(N-(p-trifluoromethylbenzoyl)-(2′R,3′S)-3′-phenylisoserinate)

Bioorganic & Medicinal Chemistry Letters 1992.0

Synthesis of novel taxol analogs and evaluation of their biological activities