The first selective antagonist for a GABAC receptor
Bioorganic & Medicinal Chemistry Letters
1996.0
Abstract
(1,2,5,6-Tetrahydropyridine-4-yl)methylphosphinic acid (TPMPA, 1), which is synthesized in six steps from 3-butyn-l-ol, is the first γ-aminobutyric acid (GABA) receptor antagonist that shows strong selectivity for mammalian GABAc receptors.