The first selective antagonist for a GABAC receptor

Bioorganic & Medicinal Chemistry Letters
1996.0

Abstract

(1,2,5,6-Tetrahydropyridine-4-yl)methylphosphinic acid (TPMPA, 1), which is synthesized in six steps from 3-butyn-l-ol, is the first γ-aminobutyric acid (GABA) receptor antagonist that shows strong selectivity for mammalian GABAc receptors.

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