Examination of the role of the duocarmycin SA methoxy substituents: Identification of the minimum, fully potent DNA binding subunit

Examination of the role of the duocarmycin SA methoxy substituents: Identification of the minimum, fully potent DNA binding subunit Synthesis and evaluation of a series of C5′-substituted duocarmycin SA analogs Duocarmycins, Potent Antitumor Antibiotics Produced by Streptomyces sp. Structures and Chemistry. Synthesis and evaluation of duocarmycin SA analogs incorporating the methyl 1,2,8,8a-tetrahydrocyclopropa[c]imidazolo[4,5-e]indol-4-one-6-carboxylate (CImI) alkylation subunit Synthesis and evaluation of duocarmycin SA analogs incorporating the methyl 1,2,8,8a-tetrahydrocyclopropa[c]oxazolo[2,3-e]indol-4-one-6-carboxylate (COI) alkylation subunit Synthesis and evaluation of a thio analogue of duocarmycin SA Bifunctional alkylating agents derived from duocarmycin SA: potent antitumor activity with altered sequence selectivity Duocarmycins, new antitumor antibiotics produced by Streptomyces; Producing organisms and improved production. Synthesis and antitumor activity of novel duocarmycin derivatives New antitumor antibiotics, duocarmycins B1 and B2.