Bifunctional alkylating agents derived from duocarmycin SA: potent antitumor activity with altered sequence selectivity

Bifunctional alkylating agents derived from duocarmycin SA: potent antitumor activity with altered sequence selectivity Alkylation of duplex DNA in nucleosome core particles by duocarmycin SA and yatakemycin Synthesis and antitumor activity of novel duocarmycin derivatives Synthesis and evaluation of a series of C5′-substituted duocarmycin SA analogs Examination of the role of the duocarmycin SA methoxy substituents: Identification of the minimum, fully potent DNA binding subunit Synthesis and evaluation of duocarmycin SA analogs incorporating the methyl 1,2,8,8a-tetrahydrocyclopropa[c]imidazolo[4,5-e]indol-4-one-6-carboxylate (CImI) alkylation subunit Duocarmycins, Potent Antitumor Antibiotics Produced by Streptomyces sp. Structures and Chemistry. Synthesis and evaluation of a thio analogue of duocarmycin SA Structures of Duocarmycins, novel antitumor antibiotics produced by Streptomyces sp. Duocarmycins, new antitumor antibiotics produced by Streptomyces; Producing organisms and improved production.