Synthesis and evaluation of a series of C5′-substituted duocarmycin SA analogs

Synthesis and evaluation of a series of C5′-substituted duocarmycin SA analogs Examination of the role of the duocarmycin SA methoxy substituents: Identification of the minimum, fully potent DNA binding subunit Synthesis and evaluation of duocarmycin SA analogs incorporating the methyl 1,2,8,8a-tetrahydrocyclopropa[c]imidazolo[4,5-e]indol-4-one-6-carboxylate (CImI) alkylation subunit Synthesis and evaluation of a thio analogue of duocarmycin SA Bifunctional alkylating agents derived from duocarmycin SA: potent antitumor activity with altered sequence selectivity Synthesis and evaluation of duocarmycin SA analogs incorporating the methyl 1,2,8,8a-tetrahydrocyclopropa[c]oxazolo[2,3-e]indol-4-one-6-carboxylate (COI) alkylation subunit Synthesis and antitumor activity of novel duocarmycin derivatives CC-1065 Analogues Bearing Different DNA-Binding Subunits:  Synthesis, Antitumor Activity, and Preliminary Toxicity Study Duocarmycins, Potent Antitumor Antibiotics Produced by Streptomyces sp. Structures and Chemistry. Synthesis and DNA-binding properties of polyamine analogs