Recognition in molecularly imprinted polymer α2-adrenoreceptor mimics

Bioorganic & Medicinal Chemistry Letters
1996.0

Abstract

Molecularly imprinted polymers (MIPs) selective for the α2-adrenoreceptor antagonist yohimbine (1) have been prepared and studied as α2-adrenoreceptor mimics. Marked ligand stereoselectivity was demonstrated in radioligand binding and HPLC studies upon comparison to blank and corynanthine (2) MIPs. K D values in the nanomolar range have been shown for anti-1 MIP prepared in chloroform solutions upon rebinding in organic media.

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