Synthesis and antibacterial activity of 2α-functionalized 1β-methylcarbapenems related to KR-21012

Bioorganic & Medicinal Chemistry Letters
2000.0

Abstract

The 2alpha-functionalized 1beta-methylcarbapenems 3 were synthesized from the 2-formyl 1beta-methylcarbapenem intermediate 5. The best compound in the series of 2alpha-(hydroxy)alkylcarbapenems, KR-21012, displayed well balanced in vitro and in vivo activity as a parent compound of oral carbapenem.

Knowledge Graph

Similar Paper

Synthesis and antibacterial activity of 2α-functionalized 1β-methylcarbapenems related to KR-21012
Bioorganic & Medicinal Chemistry Letters 2000.0
Studies on β-lactam antibiotics. Synthesis and antibacterial activity of novel 1β-methylcarbapenems related to FR21818: 5-membered ring analogs
Bioorganic & Medicinal Chemistry Letters 1997.0
Synthesis and biological properties of new 1β-methylcarbapenems
Bioorganic & Medicinal Chemistry Letters 1998.0
Synthesis and structure-activity relationships of novel THF 1β-methylcarbapenems
Bioorganic & Medicinal Chemistry Letters 1997.0
Synthesis and antibacterial activity of 2-functionalized-vinyl 1β-methylcarbapenems and related compounds
Bioorganic & Medicinal Chemistry Letters 1993.0
Synthesis and biological evaluation of novel 1β-methylcarbapenems having a new moiety at C-2
Bioorganic & Medicinal Chemistry Letters 1999.0
Synthesis and structure-activity relationships of novel THF 1β-methylcarbapenems II
Bioorganic & Medicinal Chemistry Letters 1997.0
Synthesis and antibacterial activity of FR21818, a new, potent 1β-methylcarbapenem
Bioorganic & Medicinal Chemistry Letters 1995.0
Synthesis and biological activity of novel 1β-Methylcarbapenems with oxyiminopyrrolidinylamide moiety
Bioorganic & Medicinal Chemistry Letters 2003.0
Synthesis and antibacterial evaluation of 1β-methyl-2-[5-(1-methoxyimino-2-substituted sulfonamide ethyl)pyrrolidin-3-ylthio]carbapenems and their related compounds
European Journal of Medicinal Chemistry 2007.0