4-(3-furyl)-2-(4-methylpiperazino)pyrimidines: Potent 5-HT2A receptor antagonists

Bioorganic & Medicinal Chemistry Letters
1997.0

Abstract

The title pyrimidines 7-12 are potent 5-HT2A receptor ligands with fairly strong behavioral antagonistic activity. A comparison of the structural and binding properties within the entire group of these and other pyrimidines demonstrates two different modes of the bioactive complex formation.

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