Dimeric aminoglycosides: Design, synthesis and RNA binding

Bioorganic & Medicinal Chemistry Letters
1997.0

Abstract

The design and synthesis of symmetrical and non-symmetrical dimeric aminoglycosides derived from kanamycin A, tobramycin, and neomycin B are described. The covalently-linked dimeric aminoglycosides show enhanced activity as ribozyme inhibitors when compared to their natural counterparts.

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