Novel synthesis and RNA-Binding properties of aminoglycoside dimers conjugated via a naphthalene diimide-based intercalator

Novel synthesis and RNA-Binding properties of aminoglycoside dimers conjugated via a naphthalene diimide-based intercalator Enhanced binding of aminoglycoside dimers to a “dimerized” A-site 16S rRNA construct Linker dependent intercalation of bisbenzimidazole-aminosugars in an RNA duplex; selectivity in RNA vs . DNA binding Dimeric aminoglycosides: Design, synthesis and RNA binding Studies on the synthesis of neamine-dinucleosides and neamine-PNA conjugates and their interaction with RNA Binding of Aminoglycoside Antibiotics with Modified A-site 16S rRNA Construct Containing Non-Nucleotide Linkers Binding of dimeric aminoglycosides to the HIV-1 rev responsive element (RRE) RNA construct Molecular recognition of a DNA:RNA hybrid: Sub-nanomolar binding by a neomycin–methidium conjugate Conjugate of neamine and 2-deoxystreptamine mimic connected by an amide bond Neamine dimers targeting the HIV-1 TAR RNA