A simplified template approach towards the synthesis of a potent beta-3 adrenoceptor agonist at the human receptor

Bioorganic & Medicinal Chemistry Letters
1997.0

Abstract

A simplified template approach was used to delineate the structural requirements for high potency and intrinsic activity of aryloxypropanolamines as agonists at the human beta-3 adrenoceptor. The information generated was used to prepare selective beta-3 adrenoceptor agonists.

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