Discovery of a novel, potent and selective human β3-adrenergic receptor agonist

Bioorganic & Medicinal Chemistry Letters
2005.0

Abstract

The discovery of a novel, potent and selective beta(3)-adrenergic receptor (AR) agonist is described. SAR studies demonstrated the structural requirements for activity and selectivity. Compound 1c, which showed good beta(3)-AR activity and selectivity, was identified and pharmacokinetics were investigated.

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