N-(2-(4-hydroxyphenyl)ethyl)-4-chlorocinnamide: A novel antagonist at the 1a/2B NMDA receptor subtype

Bioorganic & Medicinal Chemistry Letters
1998.0

Abstract

A series of N-(2-phenethyl)cinnamides was synthesized and assayed for antagonism at three N-methyl-D-asparate (NMDA) receptor subtypes (NR1A/2A-C). N-(2-(4-hydroxyphenyl)ethyl)-4-chlorocinnamide (6) was identified as a highly potent and selective antagonist of the NR1A/2B subtype.

Knowledge Graph

Similar Paper

N-(2-(4-hydroxyphenyl)ethyl)-4-chlorocinnamide: A novel antagonist at the 1a/2B NMDA receptor subtype
Bioorganic & Medicinal Chemistry Letters 1998.0
Structure−Activity Relationship of N-(Phenylalkyl)cinnamides as Novel NR2B Subtype-Selective NMDA Receptor Antagonists
Journal of Medicinal Chemistry 1999.0
4-Aminoquinolines as a novel class of NR1/2B subtype selective NMDA receptor antagonists
Bioorganic & Medicinal Chemistry Letters 2002.0
Hydroxymethyl bioisosteres of phenolic GluN2B-selective NMDA receptor antagonists: Design, synthesis and pharmacological evaluation
European Journal of Medicinal Chemistry 2018.0
2,6-Disubstituted pyrazines and related analogs as NR2B site antagonists of the NMDA receptor with anti-depressant activity
Bioorganic & Medicinal Chemistry Letters 2011.0
Enantiomeric Propanolamines as selectiveN-Methyl-<scp>d</scp>-aspartate 2B Receptor Antagonists
Journal of Medicinal Chemistry 2008.0
Identification and Characterization of 4-Methylbenzyl 4-[(Pyrimidin-2-ylamino)methyl]piperidine-1-carboxylate, an Orally Bioavailable, Brain Penetrant NR2B SelectiveN-Methyl-<scp>d</scp>-Aspartate Receptor Antagonist
Journal of Medicinal Chemistry 2007.0
Development of 2′-Substituted (2S,1′R,2′S)-2-(Carboxycyclopropyl)glycine Analogues as Potent N-Methyl-<scp>d</scp>-aspartic Acid Receptor Agonists
Journal of Medicinal Chemistry 2013.0
Potent quinoxaline-spaced phosphono .alpha.-amino acids of the AP-6 type as competitive NMDA antagonists: synthesis and biological evaluation
Journal of Medicinal Chemistry 1993.0
Structural Investigation of the 7-Chloro-3-hydroxy-1H-quinazoline-2,4-dione Scaffold to Obtain AMPA and Kainate Receptor Selective Antagonists. Synthesis, Pharmacological, and Molecular Modeling Studies
Journal of Medicinal Chemistry 2006.0