4-Aminoquinolines as a novel class of NR1/2B subtype selective NMDA receptor antagonists

Bioorganic & Medicinal Chemistry Letters
2002.0

Abstract

Screening of the Roche compound library led to the identification of 4-aminoquinoline 4 as structurally novel NR1/2B subtype selective NMDA receptor antagonist. The SAR which was developed in this series resulted in the discovery of highly potent and in vivo active blockers.

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