Manipulation of the C(22)-C(27) region of rapamycin: Stability issues and biological implications

Manipulation of the C(22)-C(27) region of rapamycin: Stability issues and biological implications Structure-activity studies of nonmacrocyclic rapamycin derivatives Antifungal rapamycin analogues with reduced immunosuppressive activity Cleavage of the cyclohexyl-subunit of rapamycin results in loss of immunosuppressive activity Generation of Novel Rapamycin Structures by Microbial Manipulations. Rapamycin analogs with reduced systemic exposure Novel derivatives at the C21 position of the FK-506 macrocycle The Rapamycin-binding Domain of the Protein Kinase Mammalian Target of Rapamycin Is a Destabilizing Domain Isolation, Structure Determination and Biological Activity of 15-Deoxo-7,32-O-didesmethylrapamycin from the Soil Actinomycete LL-D45042 Synthesis and biological evaluation of rapamycin-derived, next generation small molecules