The synthesis and evaluation of cyclic ureas as HIV protease inhibitors: Modifications of the P1/P1′ residues

Bioorganic & Medicinal Chemistry Letters
1998.0

Abstract

Two series of cyclic ureas modified at the P1/P1' residue were prepared and evaluated for HIV protease inhibition and whole cell antiviral activity. Compounds 8b, 10 (3- and 4-pyridylmethyl analogs) and 6b (4-methoxy analog) showed significant improvement in antiviral activity relative to lead compounds DMP323 and DMP 450.

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