Studies on an immunosuppressive macrolactam, ascomycin: Synthesis of a C-33 hydroxyl derivative

Studies on an immunosuppressive macrolactam, ascomycin: Synthesis of a C-33 hydroxyl derivative C32-O-imidazol-2-yl-methyl ether derivatives of the immunosuppressant ascomycin with improved therapeutic potential The C-32 Triacetyl-L-rhamnose Derivative of Ascomycin: A Potent, Orally Active Macrolactone Immunosuppressant Alkyl ether derivatives of the FK-506 related, immunosuppressive macrolide L-683,742 (C31-O-desmethyl ascomycin) Microbial transformations of immunosuppressive compounds. IV. Hydroxylation and hemiketal formation of ascomycin(immunomycin) by Streptomyces sp. MA6970(ATCC No.55281). 32-Ascomycinyloxyacetic Acid Derived Immunosuppressants. Independence of Immunophilin Binding and Immunosuppressive Potency C32-amino derivatives of the immunosuppressant ascomycin Potent immunosuppressive C32-O-arylethyl ether derivatives of ascomycin with reduced toxicity Alkyl ether analogs of the FK-506 related, immunosuppressive macrolide L-683,590 (ascomycin) Retention of Immunosuppressant Activity in an Ascomycin Analogue Lacking a Hydrogen-Bonding Interaction with FKBP12