Synthesis and biological evaluation of α-mannosidase inhibitory activity of three deoxy derivatives of mannostatin A

Bioorganic & Medicinal Chemistry Letters
1999.0

Abstract

Three deoxy derivatives of alpha-mannosidase inhibitor mannostatin A have been synthesized and their inhibitors activity for Jack beans alpha-mannosidase evaluated in order to elucidate roles of each hydroxyl groups of the inhibitor The 1- and 2-deoxy derivatives have preserved inhibitory potentials although they lowered the activity one-hundred fold compared to the parent, but the 3-deoxy derivative lost activity.

Knowledge Graph

Similar Paper

Synthesis and biological evaluation of α-mannosidase inhibitory activity of three deoxy derivatives of mannostatin A
Bioorganic & Medicinal Chemistry Letters 1999.0
Synthesis of a potent aminocyclitol α-mannosidase inhibitor, 1 l -(1,2,3,5/4)-5-amino-4- O -methyl-1,2,3,4-cyclopentanetetrol
Bioorganic & Medicinal Chemistry Letters 2000.0
α-d-Mannose derivatives as models designed for selective inhibition of Golgi α-mannosidase II
European Journal of Medicinal Chemistry 2011.0
Synthesis of inhibitors of α-1,3-fucosyltransferase
Bioorganic & Medicinal Chemistry Letters 1997.0
Synthesis and biological activity of C-6 modified derivatives of the glucosidase inhibitor 1-deoxynojirimycin.
Bioorganic & Medicinal Chemistry Letters 1992.0
Synthesis and biological evaluation of novel 8-aminomethylated oroxylin A analogues as α-glucosidase inhibitors
Bioorganic & Medicinal Chemistry Letters 2008.0
α-1-C-Alkyl-1-deoxynojirimycin derivatives as potent and selective inhibitors of intestinal isomaltase: remarkable effect of the alkyl chain length on glycosidase inhibitory profile
Bioorganic & Medicinal Chemistry Letters 2004.0
Synthesis of anomeric 1,5-anhydrosugars as conformationally locked selective α-mannosidase inhibitors
Bioorganic & Medicinal Chemistry 2011.0
New deoxynojirimycin derivatives as potent inhibitors of intestinal α-glucohydrolases
Bioorganic & Medicinal Chemistry Letters 1997.0
Novel 2-[(benzylamino)methyl]pyrrolidine-3,4-diol derivatives as α-mannosidase inhibitors and with antitumor activities against hematological and solid malignancies
Bioorganic & Medicinal Chemistry 2010.0