The structure-based design and synthesis of selective inhibitors of trypanosoma cruzi dihydrofolate reductase

The structure-based design and synthesis of selective inhibitors of trypanosoma cruzi dihydrofolate reductase Design, Synthesis, and Evaluation of Inhibitors of Trypanosomal and Leishmanial Dihydrofolate Reductase Structure-guided discovery of selective methionyl-tRNA synthetase inhibitors with potent activity against Trypanosoma brucei New trypanocidal hybrid compounds from the association of hydrazone moieties and benzofuroxan heterocycle Privileged structure-guided synthesis of quinazoline derivatives as inhibitors of trypanothione reductase Inhibition of Trypanosoma cruzi Trypanothione Reductase by Acridines:  Kinetic Studies and Structure−Activity Relationships Rational design of nitrofuran derivatives: Synthesis and valuation as inhibitors of Trypanosoma cruzi trypanothione reductase Inhibitors ofTrypanosoma cruziTrypanothione Reductase Revealed by Virtual Screening and Parallel Synthesis Selective Inhibition of Trypanosomal Glyceraldehyde-3-phosphate Dehydrogenase by Protein Structure-Based Design: Toward New Drugs for the Treatment of Sleeping Sickness Natural-product-inspired design and synthesis of two series of compounds active against Trypanosoma cruzi: Insights into structure–activity relationship, toxicity, and mechanism of action