SAR in the alkoxy lactone series: the discovery of DFP, a potent and orally active COX-2 inhibitor

SAR in the alkoxy lactone series: the discovery of DFP, a potent and orally active COX-2 inhibitor Discovery of a potent and selective COX-2 inhibitor in the alkoxy lactone series with optimized metabolic profile A new structural variation on the methanesulfonylphenyl class of selective cyclooxygenase-2 inhibitors 2,2-Dimethyl-4,5-diaryl-3(2 H )furanone derivatives as selective cyclo-oxygenase-2 inhibitors Synthesis and biological evaluation of 3-heteroaryloxy-4-phenyl-2(5H)-furanones as selective COX-2 inhibitors 6-Alkyl, alkoxy, or alkylthio-substituted 3-(4-methanesulfonylphenyl)-4-phenylpyran-2-ones: a novel class of diarylheterocyclic selective cyclooxygenase-2 inhibitors Discovery of a potent, selective and orally active canine COX-2 inhibitor, 2-(3-difluoromethyl-5-phenyl-pyrazol-1-yl)-5-methanesulfonyl-pyridine In Vitro Structure−Activity Relationship and in Vivo Studies for a Novel Class of Cyclooxygenase-2 Inhibitors:  5-Aryl-2,2-dialkyl-4-phenyl-3(2H)furanone Derivatives A prodrug approach to COX-2 inhibitors with methylsulfone 2-Heterosubstituted-3-(4-methylsulfonyl)phenyl-5-trifluoromethyl pyridines as selective and orally active cyclooxygenase-2 inhibitors