A new structural variation on the methanesulfonylphenyl class of selective cyclooxygenase-2 inhibitors

A new structural variation on the methanesulfonylphenyl class of selective cyclooxygenase-2 inhibitors Discovery of a potent and selective COX-2 inhibitor in the alkoxy lactone series with optimized metabolic profile 2,2-Dimethyl-4,5-diaryl-3(2 H )furanone derivatives as selective cyclo-oxygenase-2 inhibitors SAR in the alkoxy lactone series: the discovery of DFP, a potent and orally active COX-2 inhibitor In Vitro Structure−Activity Relationship and in Vivo Studies for a Novel Class of Cyclooxygenase-2 Inhibitors:  5-Aryl-2,2-dialkyl-4-phenyl-3(2H)furanone Derivatives 2,3-Diarylcyclopentenones as Orally Active, Highly Selective Cyclooxygenase-2 Inhibitors Cyclooxygenase-2 Inhibitors. Synthesis and Pharmacological Activities of 5-Methanesulfonamido-1-indanone Derivatives A prodrug approach to COX-2 inhibitors with methylsulfone 2-Heterosubstituted-3-(4-methylsulfonyl)phenyl-5-trifluoromethyl pyridines as selective and orally active cyclooxygenase-2 inhibitors Conformationally restricted 3,4-diarylfuranones (2,3a,4,5-tetrahydronaphthofuranones) as selective cyclooxygenase-2 inhibitors