Discovery of a potent and selective COX-2 inhibitor in the alkoxy lactone series with optimized metabolic profile

Discovery of a potent and selective COX-2 inhibitor in the alkoxy lactone series with optimized metabolic profile SAR in the alkoxy lactone series: the discovery of DFP, a potent and orally active COX-2 inhibitor A new structural variation on the methanesulfonylphenyl class of selective cyclooxygenase-2 inhibitors A prodrug approach to COX-2 inhibitors with methylsulfone 2,2-Dimethyl-4,5-diaryl-3(2 H )furanone derivatives as selective cyclo-oxygenase-2 inhibitors 6-Alkyl, alkoxy, or alkylthio-substituted 3-(4-methanesulfonylphenyl)-4-phenylpyran-2-ones: a novel class of diarylheterocyclic selective cyclooxygenase-2 inhibitors The novel benzopyran class of selective cyclooxygenase-2 inhibitors-part I: The first clinical candidate In Vitro Structure−Activity Relationship and in Vivo Studies for a Novel Class of Cyclooxygenase-2 Inhibitors:  5-Aryl-2,2-dialkyl-4-phenyl-3(2H)furanone Derivatives Synthesis and biological evaluation of 3-heteroaryloxy-4-phenyl-2(5H)-furanones as selective COX-2 inhibitors Cyclooxygenase-2 Inhibitors. Synthesis and Pharmacological Activities of 5-Methanesulfonamido-1-indanone Derivatives